The area was a feud of the Venetian aristocrat Dei Mezzo from the great Dei Mezzo family, which is one of the most populous families of Sitia. Dei Mezzo built the villa that bears its name and is one of the most important Venetian monuments of the Cretan country side.

The building had a rectangular shape with an entry hall covered by arches; as was the main dining hall and the corridor. All the auxiliary structures around the mansion were probably built during the Ottoman reign. Many engravings and the escutcheon of the Dei Mezzo family can also be found.

The villa was built at end of the 15th century, the same time the Toplou monastery was built and it was preserved intact until 1828. The building was surrounded by a big yard and was protected by walls. The main gate was palatial and bore the coat of arms of the Dei Mezzo family. On the eastern side of the yard close to the door, a fountain was found; the water was passed to the basin along the road.